Criteria for response in patients in clinical trials of empiric antibiotic regimens for febrile neutropenia. Is there agreement?

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ID: 117702
1970
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Abstract
A review of the literature on the criteria of response in patients on clinical trials of empiric antibiotic therapy revealed that there are at least three definitions utilized worldwide along with individual investigator definitions. The main definitions include definitions by Pizzo from the NCI, by the EORTC Antimicrobial group and by the Immunocompromised Host Society. The outcome in clinical trials can be affected by the definition used if the major endpoint in the study compares response rates of two or more initial empiric antimicrobial regimens for febrile neutropenia. Survival based definitions (Pizzo) are very useful but may not identify which regimen required the least number of modifications during the critical initial 3-5 days of trial. Evaluations later in the course of the febrile episode will not likely be influenced by these definitions as most patients with prolonged and severe neutropenia will eventually require modifications of therapy. A consensus to use a single response definition is necessary to allow comparisons and meta-analysis of results with specific antibiotic regimens for febrile neutropenia. These must be enforced by editors of major medical journals to truly allow this to happen.
Reference Key
feld1970supportivecriteria Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ronald Feld;Ronald Feld;
Journal supportive care in cancer
Year 1970
DOI
doi:10.1007/s005200050192
URL
http://dx.doi.org/10.1007/s005200050192
Keywords
Nursing oncology nursing research rehabilitation medicine pain medicine National Center for Biotechnology Information NCBI NLM MEDLINE review humans pubmed abstract nih national institutes of health national library of medicine treatment outcome neoplasms / drug therapy reference values neutropenia / chemically induced neutropenia / drug therapy* fever / drug therapy anti-bacterial agents / therapeutic use* fever / complications r feld pmid:9773461 doi:10.1007/s005200050192 clinical trials as topic / standards* research design / standards*

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