Progress in Microneedle-Mediated Protein Delivery

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ID: 117610
2020
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Abstract
The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.
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jamaledin2020journalprogress Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rezvan Jamaledin;Concetta Di Natale;Valentina Onesto;Zahra Baghban Taraghdari;Ehsan Nazarzadeh Zare;Pooyan Makvandi;Raffaele Vecchione;Paolo Antonio Netti;Jamaledin, Rezvan;Di Natale, Concetta;Onesto, Valentina;Taraghdari, Zahra Baghban;Zare, Ehsan Nazarzadeh;Makvandi, Pooyan;Vecchione, Raffaele;Netti, Paolo Antonio;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9020542
URL
https://www.mdpi.com/2077-0383/9/2/542
Keywords
drug delivery protein transdermal antigen delivery microneedles

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