Early Pregnancy Vitamin D Binding Protein Is Independently Associated with the Development of Gestational Diabetes: A Retrospective Cohort Study

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ID: 117009
2020
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Abstract
Background: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites. However, human studies exploring these metabolites in pregnancy remain sparse. Here, we examine whether VDBP and total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D) metabolites in early pregnancy are associated with subsequent adverse pregnancy outcomes. Methods: We conducted a retrospective analysis of 304 pregnant women in early pregnancy (p = 0.015). This finding remained significant after adjustment for maternal covariates including age, BMI, and ethnicity (β = −0.003, p = 0.03). Lower total, free and bioavailable 25(OH)D, but not VDBP, were associated with a shorter length of gestation, but only the relationship with total 25(OH)D remained significant after adjustment for the above maternal covariates (β = 0.02, p = 0.006). Conclusions: This is the first study to examine VDBP, and total, free and bioavailable 25(OH)D in relation to pregnancy outcomes in a well characterised multi-ethnic cohort of pregnant women. Our findings show that VDBP and total 25(OH)D are associated with GDM and length of gestation, respectively; however, further investigations using large-scale prospective studies are needed to confirm our findings.
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mousa2020journalearly Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Melinda Fernando,Stacey J. Ellery,Deborah De Guingand,Clara Marquina,Siew Lim,Cheryce L. Harrison,Helena J. Teede,Negar Naderpoor,Aya Mousa;Melinda Fernando;Stacey J. Ellery;Deborah De Guingand;Clara Marquina;Siew Lim;Cheryce L. Harrison;Helena J. Teede;Negar Naderpoor;Aya Mousa;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9072186
URL
https://sciprofiles.com/publication/view/5187e556d9bfdf7d3c8268ab6be0e9c6
Keywords
pregnancy gestational diabetes mellitus glucose tolerance bioavailable vitamin d vitamin d binding protein free vitamin d pregnancy gestational diabetes mellitus glucose tolerance bioavailable vitamin d vitamin d binding protein free vitamin d

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