A histochemical study of motor neurone disease

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ID: 116866
1970
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Abstract
Enzymes functioning in the major metabolic pathways of the central nervous system have been examined in 5 cases of motor neurone disease. Surviving motor nerve cells exhibited a normal response to all enzymes except ATPase and 5-nucleotidase. Nerve cells exhibiting partial degeneration showed a stronger activity of some enzymes (AChE, NADH2 diaphorase, G6-PDH) than others (ATPase, 5-nucleotidase, monoamine oxidase). Complete enzymic loss was evident in some anterior horn motor nerve cells. Striking alterations in NADH2 diaphorase, G6-PDH, acid phosphatase and thiamine pyrophosphatase activities were observed in swollen astrocytes in the internal capsule, the lateral corticospinal tract and frequently in the anterior corticospinal tract. PAS-positive material was depleted in these areas. The findings are discussed biochemically and in relation to other disorders of the central nervous system.
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robinson1970actaa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors N. Robinson
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Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00686777
URL
https://link.springer.com/article/10.1007/BF00686777
Keywords
pathology neurosciences

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