Electron microscopic study of metachromatic leucodystrophy

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ID: 116542
1970
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Abstract
In metachromatic leucodystrophy abnormal lipids are stored within the lysosomes of the glial cells and phagocytes. The lipid inclusions which are the less structured are the richest in acid phosphatases. Those of which the ultrastructure is prismatic show a very low enzymatic activity and are more similar to residual bodies than to active lysosomes. It appears that the lack in lysosomal arylsulfatase leads to an accumulation of the sulfatide moiety of the stored lipids while the other lipids originating from the myelin breakdown, would be normally catabolized. This leads to a progressive transformation of the ultrastructure of the lysosome contents.
Reference Key
résibois1970actaelectron Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anne Résibois;Anne Résibois;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687027
URL
https://link.springer.com/article/10.1007/BF00687027
Keywords
pathology neurosciences

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