Structural studies of a water insoluble β-glucan from Pleurotus djamor and its cytotoxic effect against PA1, ovarian carcinoma cells.

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ID: 11637
2019
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Ranked #74 of 138 articles by views in Carbohydrate polymers

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Abstract
A water insoluble β-glucan (PS), with molecular mass ∼9.16 × 10 Da was isolated from the 4% alkaline extract of an edible mushroom, Pleurotus djamor and found to consist of (1→3)-β-d-glucopyranosyl moiety. The structure of the PS was elucidated on the basis of total hydrolysis, methylation analysis, periodate oxidation, and NMR experiments (H, C, DQF-COSY, DEPT-135, and HSQC). The structure of the repeating unit of the polysaccharide was established as: →3)-β-d-Glcp-(1→. The water insoluble β-glucan showed cytotoxic effect against PA1 cells, where˜50% population was destroyed at 100 μg/mL concentration, and almost all cells at 250 μg/mL concentration. The wound healing assay showed significant anticarcinogenic effect against ovarian carcinoma PA1 cells after 48 h of treatment.
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maity2019structuralcarbohydrate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Maity, Gajendra Nath;Maity, Prasenjit;Choudhuri, Indranil;Bhattacharyya, Nandan;Acharya, Krishnendu;Dalai, Sudipta;Mondal, Soumitra;
Journal Carbohydrate polymers
Year 2019
DOI
S0144-8617(19)30650-2
URL
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