Morphometric comparison of hippocampal microvasculature in ageing and demented people: Diameters and densities

Clicks: 172
ID: 116144
1981
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #218 of 438 articles by views in acta neuropathologica

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 438 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The diameters and densities of capillaries and arterioles in the hippocampal cortex of normal subjects and patients with Alzheimer's dementia were measured in thick celloidin sections stained for alkaline phosphatase. Microvascular diameters in general are affected more by age than by the presence of dementia of the Alzheimer type. The diameter of both capillaries and arterioles increases significantly with age. The density of capillaries decreases whereas that of the arterioles increases significantly. The capillary changes suggest that a reduced exchange potential accompanies ageing. In brains of people with Alzheimer's disease the overall capillary diameters and densities do not differ from those of age-matched controls. Regional changes may, however, be important: those hippocampal zones showing the greatest severity of or increment in nerve cell lesions do correspond to those having the highest levels of or increase in capillary density and the greatest decrease in diameter, suggesting a direct association between neuronal susceptibility to Alzheimer changes and degree of regional blood supply. Capillary surface areas, volumes, and area/capillary volume ratios support the possibility of this relationship. Neurofibrillary tangles and granulovacuolar degeneration do not correlate equally with the degree of capillary “irrigation” tangles are more closely related to these morphological vascular parameters.
Reference Key
bell1981actamorphometric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mary A. Bell;M. J. Ball;Mary A. Bell;M. J. Ball;
Journal acta neuropathologica
Year 1981
DOI
doi:10.1007/BF00690372
URL
https://link.springer.com/article/10.1007/BF00690372
Keywords
pathology neurosciences

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.