Effectiveness and Nephrotoxicity of Long-Term Tacrolimus Administration in Patients with Ulcerative Colitis

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ID: 115895
2020
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Abstract
Background: Tacrolimus (TAC) is used for the management of ulcerative colitis (UC). However, there are few reports on the effectiveness of its long-term administration. TAC is also known to cause renal toxicity. The aim of this study was to evaluate long-term effectiveness and monitor changes in renal function during prolonged TAC use in patients with UC. Methods: Medical records of 50 UC patients treated with TAC were retrospectively reviewed. Clinical outcomes were assessed at 6, 12, 24, and 36 months after initiating TAC. We also monitored chronological changes in renal function. Results: Thirty-nine patients were treated with TAC for more than 3 months. Relapse-free survival among these patients at 6, 12, 24, and 36 months was 82%, 69%, 41%, and 23%, respectively. On the other hand, renal function was reduced in 35.9% of patients. We found that irreversible renal dysfunction was more likely to occur in cases in which the estimated glomerular-filtration rate (eGFR) was reduced by more than 30%. Conclusion: This study demonstrated the potential use of TAC as an effective option in the long-term medical management of UC, although it tended to increase the risk of nephrotoxicity. There is a need for the careful monitoring of renal function during TAC administration.
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haga2020journaleffectiveness Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Keiichi Haga;Tomoyoshi Shibuya;Kei Nomura;Koki Okahara;Osamu Nomura;Dai Ishikawa;Naoto Sakamoto;Taro Osada;Akihito Nagahara;Haga, Keiichi;Shibuya, Tomoyoshi;Nomura, Kei;Okahara, Koki;Nomura, Osamu;Ishikawa, Dai;Sakamoto, Naoto;Osada, Taro;Nagahara, Akihito;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9061771
URL
https://www.mdpi.com/2077-0383/9/6/1771
Keywords
ulcerative colitis tacrolimus inflammatory bowel disease renal function

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