Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats

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ID: 115859
1970
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Abstract
We performed a morphological, morphometric and toxicological study on the spinal ganglia and peripheral nerves of the rat after chronic administration of cisplatin (cis-dichlorodiammineplatinum II; DDP) with two different schedules. Severe damage of the spinal ganglia neurons was demonstrated with predominant involvement of the nucleus and nucleolus associated with a decrease in the cell size. Morphological and morphometric changes also occurred in the sciatic and peroneal nerves with the features of axonopathy. All these changes were more marked in the group of rats which underwent the most intense DDP treatment and the tissue platinum concentrations were also higher in this group. This experimental model is the first available for chronic DDP administration in which concomitant spinal ganglia and peripheral nerve damage has been confirmed pathologically. Our study supports the hypothesis that DDP-induced peripheral nerve fiber degeneration may result from nuclear and nucleolar changes in the sensory ganglion cell perikaryon.
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cavaletti1970actamorphometric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors G. Cavaletti;G. Tredici;P. Marmiroli;M. G. Petruccioli;I. Barajon;D. Fabbrica;G. Cavaletti;G. Tredici;P. Marmiroli;M. G. Petruccioli;I. Barajon;D. Fabbrica;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00227662
URL
https://link.springer.com/article/10.1007/BF00227662
Keywords
pathology neurosciences

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