Nanomaterials multifunctional behavior for enlighten cancer therapeutics.

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ID: 11580
2019
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Ranked #5 of 136 articles by views in seminars in cancer biology

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Abstract
Cancer is an outrageous disease with uncontrolled differentiation, growth, and migration to the other parts of the body. It is the second-most common cause of death both in the U.S. and worldwide. Current conventional therapies, though much improved and with better prognosis, have several limitations. Chemotherapeutic agents, for instance, are cytotoxic to both tumor and healthy cells, and the non-specific distribution of drugs at tumor sites limits the dose administered. Nanotechnology, which evolved from the coalescence and union of varied scientific disciplines, is a novel science that has been the focus of much research. This technology is generating more effective cancer therapies to overcome biomedical and biophysical barriers against standard interventions in the body; its unique magnetic, electrical, and structural properties make it a promising tool. This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.
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ganji2019nanomaterialsseminars Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ganji, Seeta Rama Raju;Dariya, Begum;Mungamuri, Sathish Kumar;Chalikonda, Gayathri;Kang, Sung-Min;Khan, Ishaq N;Sushma, Pinninti Santosh;Nagaraju, Ganji Purnachandra;Pavitra, Eluri;Han, Young-Kyu;
Journal seminars in cancer biology
Year 2019
DOI
S1044-579X(19)30190-7
URL
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