Erectile Dysfunction after Kidney Transplantation

Clicks: 292
ID: 115294
2020
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Abstract
Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychological changes related to chronic disease, as well as hyperprolactinemia and hypogonadism. Whenever these endocrine dysfunctions occur after kidney transplantation, they must be corrected with appropriate treatment, i.e., testosterone replacement therapy. Administration of the phosphodiesterase-5 inhibitor (PDE5i) sildenafil at the recommended posology does not significantly alter the pharmacokinetics of the calcineurin inhibitors cyclosporin A or tacrolimus and does not impair kidney allograft function. Tacrolimus increases the peak concentration and prolongs the half-life of PDE5i in kidney transplant patients and, therefore, daily administration cannot be recommended due to the significant drop in blood pressure. Intracavernous injection or topical application of alprostadil can be a second-line option for the treatment of erectile dysfunction after kidney transplantation, which does not alter cyclosporine concentrations and does not deteriorate kidney function. Finally, penile prostheses can be successfully implanted following pelvic organ transplantation after eliminating the risk of infection associated with surgery.
Reference Key
perri2020journalerectile Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anna Perri;Giulia Izzo;Danilo Lofaro;Sandro La Vignera;Antonio Brunetti;Aldo Eugenio Calogero;Antonio Aversa;Perri, Anna;Izzo, Giulia;Lofaro, Danilo;La Vignera, Sandro;Brunetti, Antonio;Calogero, Aldo Eugenio;Aversa, Antonio;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9061991
URL
https://www.mdpi.com/2077-0383/9/6/1991
Keywords
end-stage renal disease hypogonadism prolactin intracavernous injection phosphodiesterase type-5 inhibitors

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