Hirnbasisarterienveränderungen bei Marfan-Syndrom und idiopathischer Media-Nekrose

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ID: 115239
1970
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Abstract
Degenerative processes of the tunica media are reported with increasing frequency among the causes of a dissecting aneurysm in the wall of large arteries. The underlying process is supposed to be a necrosis or degeneration of elastic tissue and smooth muscle cells, occurring either in idiopathic necrosis of the media (Gsell-Erdheim) or in systemic disorders as Marfan's syndrome, pseudoxanthoma elasticum, Ehlers-Danlos-syndrome and homocystinuria. Neurological symptoms in these conditions are attributed to disturbances of general circulation but not to involvement of cerebral arteries. The findings in 3 young patients are reported (1 Marfan's syndrome, 2 patients with medianecrosis of large arteries) exhibiting the characteristic histological changes in the media of the cerebral arteries, too. Possible connections between such degenerative diseases of the tunica media and the origin of fusiform aneurysms or the “megadolicho-basilaris syndrome” of cerebral arteries are suggested.
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Authors Lieselotte Gerhard;Gabriele Schmitz-Bauer;Lieselotte Gerhard;Gabriele Schmitz-Bauer;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00697753
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