Evaluation of a Rapid Immunochromatographic Test for Detection of Streptococcus pneumoniae Antigen in Urine Samples from Adults with Community-Acquired Pneumonia

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ID: 115050
2001
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Abstract
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia but is undoubtedly underdiagnosed. Isolation of S. pneumoniae from blood is specific but lacks sensitivity, while isolation of S. pneumoniae from sputum may represent colonization. We evaluated a new immunochromatographic test (NOW S. pneumoniae urinary antigen test; Binax, Portland, Maine) that is simple to perform and that can detect S. pneumoniae antigen in urine within 15 min. Urine samples from 420 adults with community-acquired pneumonia and 169 control patients who did not have pneumonia were tested. Urine from 315 (75%) of the pneumonia patients and all controls was tested both before and after 25-fold concentration, while the remaining 105 samples were only tested without concentration. S. pneumoniae urinary antigen tests were positive for 120 (29%) patients with pneumonia and for none of the controls. Of the urine samples tested with and without concentration, 96 were positive, of which 6 were positive only after concentration. S. pneumoniae antigen was detected in the urine from 16 of the 20 (80%) patients with blood cultures positive for S. pneumoniae and from 28 of the 54 (52%) patients with sputum cultures positive for S. pneumoniae . The absence of S. pneumoniae antigen in the urine from controls suggests that the specificity is high. Concentration of urine prior to testing resulted in a small increase in yield. The NOW S. pneumoniae urinary antigen test should be a useful adjunct to culture for determining the etiology of community-acquired pneumonia in adults.
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Authors David R. Murdoch, Richard T. R. Laing, Graham D. Mills, Noel C. Karalus, G. Ian Town, Stanley Mirrett, L. Barth Reller
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Journal Journal of clinical microbiology
Year 2001
DOI
10.1128/JCM.39.10.3495-3498.2001
URL
http://dx.doi.org/10.1128/JCM.39.10.3495-3498.2001
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male adolescent aged middle aged 80 and over Antigens Evaluation Study community-acquired infections / microbiology chromatography / methods pneumonia pneumococcal / diagnosis* pneumococcal / microbiology streptococcus pneumoniae / isolation & purification* bacterial / urine* l b reller streptococcus pneumoniae / immunology reagent kits diagnostic community-acquired infections / diagnosis* pmid:11574562 pmc88378 doi:10.1128/jcm.39.10.3495-3498.2001 d r murdoch r t laing immunoassay / methods*

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