Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice

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ID: 115034
2016
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Abstract
Nonalcoholic fatty liver disease (NAFLD), along with obesity, is increasing world-wide and is one of the major causes of chronic hepatic disease. The present study evaluated the ameliorative effect of extract of Psoralea corylifolia L. seed (PCS) on high fat diet-induced NAFLD in C57BL/6 mice after daily administration at 300 or 500 mg/kg for 12 weeks. Treatment with PCS extract significantly reduced body weight and blood glucose levels and improved glucose tolerance and insulin sensitivity. In addition, PCS extract treatment significantly attenuated lipid accumulation in liver and adipose tissue and reduced serum lipid and hepatic triglyceride levels. Furthermore, the expression of lipogenic genes and inflammatory genes were reduced, and the expression of fat oxidation-related genes was increased in the liver of PCS extract-treated mice compared with control mice. Our study suggests the therapeutic potential of PCS extract for NAFLD by inhibiting lipid accumulation and inflammation in liver.
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seo2016nutrientspsoralea Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eunhui Seo;Yoon Sin Oh;Hee-Sook Jun;Seo, Eunhui;Oh, Yoon Sin;Jun, Hee-Sook;
Journal Nutrients
Year 2016
DOI
10.3390/nu8020083
URL
https://www.mdpi.com/2072-6643/8/2/83
Keywords
Diabetes obesity nonalcoholic fatty liver disease psoralea corylifolia l. seed

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