White matter alterations following thromboembolic stroke: a β-amyloid precursor protein immunocytochemical study in rats

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ID: 114921
1970
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Abstract
Thromboembolic stroke in rats leads to a well-described pattern of histopathological and behavioral abnormalities. However, limited data are available in animal models concerning the response of the white matter to embolic events. The purpose of this study was to document patterns of white matter abnormalities using β-amyloid precursor protein (βAPP) immunocytochemistry as a marker of axonal damage. Twelve male Wistar rats underwent photochemically induced right common carotid artery thrombosis (CCAT) or sham procedures. At 3 days after CCAT, rats were perfusion-fixed and sections immunostained for the visualization of βAPP or stained with hematoxylin and eosin for routine histopathological analysis. As previously described, CCAT produced small ipsilateral embolic infarcts and ischemic cell change within gray matter structures including the medial cerebral cortex, striatum, hippocampus and thalamus. In areas of frank infarction, numerous reactive profiles were observed within borderzones of the damaged site. However, βAPP immunocytochemistry also revealed reactive axonal profiles within various white matter tracts including the corpus callosum, external capsule and fimbria of the hippocampus. In many cases, the presence of axonal damage could not be appreciated with routine hematoxylin and eosin staining. These data indicate that CCAT leading to platelet embolization to the brain not only produces embolic infarcts but also produces more subtle white matter abnormalities. Previously undetected white matter damage would be expected to participate in the sensorimotor and cognitive behavioral deficits following embolic stroke.
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dietrich1970actawhite Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors W. D. Dietrich;Susan Kraydieh;Ricardo Prado;N. E. Stagliano;W. D. Dietrich;Susan Kraydieh;Ricardo Prado;N. E. Stagliano;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/s004010050833
URL
https://link.springer.com/article/10.1007/s004010050833
Keywords
pathology neurosciences

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