Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells

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ID: 114815
2019
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Abstract
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti‑cancer activity, two novel types of 1,4‑naphthoquinone derivatives, 2,3‑dihydro‑2,3‑epoxy …
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Authors Wang Y;Luo YH;Piao XJ;Shen GN;Meng LQ;Zhang Y;Wang JR;Li JQ;Wang H;Xu WT;Liu Y;Zhang Y;Zhang T;Wang SN;Sun HN;Han YH;Jin MH;Zang YQ;Zhang DJ;Jin CH;;
Journal molecular medicine reports
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/30592276/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine reactive oxygen species / metabolism Apoptosis / drug effects cell line liver neoplasms / pathology cell survival / drug effects pmid:30592276 pmc6390020 doi:10.3892/mmr.2018.9785 yue wang ying-hua luo cheng-hao jin cell proliferation / drug effects neoplastic / drug effects liver neoplasms / drug therapy* liver neoplasms / genetics map kinase signaling system / drug effects mitochondria / drug effects mitochondria / genetics naphthoquinones / pharmacology* stat3 transcription factor / genetics* p38 mitogen-activated protein kinases / genetics*

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