Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

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ID: 114802
2018
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Abstract
The dominant hypothesis of Alzheimer’s disease (AD) aetiology, the neuropathological guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both research and in clinical practice, have been built around one possible causal factor, amyloid-β (Aβ). However, the causal link between Aβ and AD remains unproven. Here, in the context of a detailed assessment of historical and contemporary studies, we raise critical questions regarding the role of Aβ in the definition, diagnosis and aetiology of AD. We illustrate that a holistic view of the available data does not support an unequivocal conclusion that Aβ has a central or unique role in AD. Instead, the data suggest alternative views of AD aetiology are potentially valid, at this time. We propose that an unbiased way forward for the field, beyond the current Aβ-centric approach, without excluding a role for Aβ, is required to come to an accurate understanding of AD dementia and, ultimately, an effective treatment.
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morris2018actaquestions Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gary P. Morris;Ian A. Clark;Bryce Vissel;Gary P. Morris;Ian A. Clark;Bryce Vissel;
Journal acta neuropathologica
Year 2018
DOI
doi:10.1007/s00401-018-1918-8
URL
https://link.springer.com/article/10.1007/s00401-018-1918-8
Keywords
pathology neurosciences

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