Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment

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2017
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Abstract
Acute lymphoblastic leukemias (ALL) positive for KMT2A/AFF1 (MLL/AF4) translocation, which constitute 60% of all infant ALL cases, have a poor prognosis even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This poor prognosis is due to one of two factors, either r …
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Authors Tamai H;Yamaguchi H;Miyake K;Takatori M;Kitano T;Yamanaka S;Yui S;Fukunaga K;Nakayama K;Inokuchi K;;
Journal Cancer research
Year 2017
DOI
DOI not found
URL
https://www.pubmed.gov/28646023/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Disease Models Animal DNA-Binding Proteins / metabolism* hiroki yamaguchi koiti inokuchi nuclear proteins / metabolism transgenic scid dna-binding proteins / genetics down-regulation pmid:28646023 doi:10.1158/0008-5472.can-16-2974 hayato tamai aminopyridines / pharmacology* anti-allergic agents / administration & dosage anti-allergic agents / pharmacology antineoplastic combined chemotherapy protocols / pharmacology* cell cycle proteins / genetics cell cycle proteins / metabolism* drug synergism inbred nod nuclear proteins / genetics precursor cell lymphoblastic leukemia-lymphoma / drug therapy* precursor cell lymphoblastic leukemia-lymphoma / metabolism precursor cell lymphoblastic leukemia-lymphoma / pathology s100 calcium binding protein a6 s100 proteins / genetics s100 proteins / metabolism* transcriptional elongation factors / genetics transcriptional elongation factors / metabolism* tumor necrosis factor-alpha / administration & dosage tumor necrosis factor-alpha / pharmacology*

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