Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment

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ID: 114701
2017
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Abstract
Acute lymphoblastic leukemias (ALL) positive for KMT2A/AFF1 (MLL/AF4) translocation, which constitute 60% of all infant ALL cases, have a poor prognosis even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This poor prognosis is due to one of two factors, either r …
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h2017canceramlexanox Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tamai H, Yamaguchi H, Miyake K, Takatori M, Kitano T, Yamanaka S, Yui S, Fukunaga K, Nakayama K, Inokuchi K
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Journal Cancer research
Year 2017
DOI
DOI not found
URL
https://www.pubmed.gov/28646023/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Disease Models Animal DNA-Binding Proteins / metabolism* hiroki yamaguchi koiti inokuchi nuclear proteins / metabolism transgenic scid dna-binding proteins / genetics down-regulation pmid:28646023 doi:10.1158/0008-5472.can-16-2974 hayato tamai aminopyridines / pharmacology* anti-allergic agents / administration & dosage anti-allergic agents / pharmacology antineoplastic combined chemotherapy protocols / pharmacology* cell cycle proteins / genetics cell cycle proteins / metabolism* drug synergism inbred nod nuclear proteins / genetics precursor cell lymphoblastic leukemia-lymphoma / drug therapy* precursor cell lymphoblastic leukemia-lymphoma / metabolism precursor cell lymphoblastic leukemia-lymphoma / pathology s100 calcium binding protein a6 s100 proteins / genetics s100 proteins / metabolism* transcriptional elongation factors / genetics transcriptional elongation factors / metabolism* tumor necrosis factor-alpha / administration & dosage tumor necrosis factor-alpha / pharmacology*

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