Persistence of Colonization of Intestinal Mucosa by a Probiotic Strain, Lactobacillus casei subsp. rhamnosus Lcr35, after Oral Consumption

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ID: 114692
2003
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Abstract
The colonization by the probiotic Lactobacillus casei subsp. rhamnosus Lcr35 of the gastrointestinal tracts of mice and humans was studied. The mice were orally given 109 CFU of Lcr35 either once or three times at 24-h intervals. A 16S ribosomal nucleic probe used in hybridization assays detected Lcr35 in the feces of mice for up to 3 days after the feeding, at a level of 108 to 109 CFU/g of feces. In the human assay, 12 healthy volunteers were enrolled in a randomized trial and ingested Lcr35 at a dosage of 108 or 1010 or 1012 CFU every day for 7 days. Then, after a 3-week posttreatment period, there was a second intake period similar to the first one. Analysis of fecal samples showed significant increases in the number of lactobacilli during the first intake period, whatever the dose given. The greatest increases were observed in subjects harboring the lowest indigenous population of Lcr35-like bacteria. During the 3-week posttreatment period, the number of CFU slightly decreased over time, and an increase, although not a statistically significant one, was observed during the second test period. These findings suggest that Lcr35 is able to survive within the gastrointestinal tract.
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Authors Christophe De Champs;Nathalie Maroncle;Damien Balestrino;Chantal Rich;Christiane Forestier;Christophe De Champs;Nathalie Maroncle;Damien Balestrino;Chantal Rich;Christiane Forestier;
Journal Journal of clinical microbiology
Year 2003
DOI
10.1128/JCM.41.3.1270-1273.2003
URL
http://dx.doi.org/10.1128/JCM.41.3.1270-1273.2003
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male adolescent Ribosomal 16S / genetics Inbred BALB C intestinal mucosa / microbiology* feces / microbiology oral probiotics / administration & dosage* pmid:12624065 pmc150315 doi:10.1128/jcm.41.3.1270-1273.2003 christophe de champs nathalie maroncle christiane forestier lactobacillus casei / physiology* 16s / analysis

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