Periventricular pathology in hydrocephalic rabbits before and after shunting

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ID: 114535
1970
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Abstract
Hydrocephalus was induced in adult rabbits by injection of silicone oil into the cisterna magna. The frontal horns of the lateral ventricles enlarged to the greatest degree and reached maximum size within 3 days. Cilia and microvilli were progressively lost from the ependymal surface primarily over the corpus callosum. Stretching and flattening of ependymal cells was most pronounced over the septal area. Mitotic activity was significantly increased among ependymal cells and subependymal astrocytes over the caudate nucleus and corpus callosum during the 2 weeks immediately following induction of hydrocephalus. Cerebrospinal fluid shunting returned the ventricles to normal size. Following shunting, however, the periventricular tissue did not resume a normal appearance. Longer durations of hydrocephalus were associated with less recovery of the periventricular tissue following shunting.
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bigio1970actaperiventricular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. R. Del Bigio;J. E. Bruni;M. R. Del Bigio;J. E. Bruni;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687430
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