In Vitro Antibiotic Susceptibilities of Yersinia pestis Determined by Broth Microdilution following CLSI Methods

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ID: 114493
2015
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Abstract
In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibility to aminoglycosides, quinolones, tetracyclines, β-lactams, cephalosporins, and carbapenems. Only a 1-well shift was observed for the majority of antibiotics between the two temperatures. Establishing and comparing antibiotic susceptibilities of a diverse but specific set of Y. pestis strains by standardized methods and establishing population ranges and MIC50 and MIC90 values provide reference information for assessing new antibiotic agents and also provide a baseline for use in monitoring any future emergence of resistance.
Reference Key
heine2015antimicrobialin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Henry S. Heine;Jeremy Hershfield;Charles Marchand;Lynda Miller;Stephanie Halasohoris;Bret K. Purcell;Patricia L. Worsham;Henry S. Heine;Jeremy Hershfield;Charles Marchand;Lynda Miller;Stephanie Halasohoris;Bret K. Purcell;Patricia L. Worsham;
Journal Antimicrobial agents and chemotherapy
Year 2015
DOI
10.1128/AAC.04548-14
URL
http://dx.doi.org/10.1128/AAC.04548-14
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Bacterial drug resistance Temperature microbial anti-bacterial agents / pharmacology* plague / microbiology microbial sensitivity tests / methods pmid:25583720 pmc4356840 doi:10.1128/aac.04548-14 henry s heine jeremy hershfield patricia l worsham colony count microbial sensitivity tests / standards yersinia pestis / drug effects*

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