Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance

Clicks: 445
ID: 114492
2011
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Abstract
In PCOS, adipose tissue has aberrant morphology/function. Increased waist-to-hip ratio indicates abdominal/visceral fat accumulation, but this is not supported by MRI. Enlarged adipocytes and reduced serum adiponectin, together with a large waistline, rather than androgen excess, may be central fact …
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Authors Mannerås-Holm L;Leonhardt H;Kullberg J;Jennische E;Odén A;Holm G;Hellström M;Lönn L;Olivecrona G;Stener-Victorin E;Lönn M;;
Journal the journal of clinical endocrinology and metabolism
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21084397
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female body mass index immunohistochemistry polycystic ovary syndrome / pathology* insulin resistance / physiology* adiponectin / blood* sex hormone-binding globulin / metabolism macrophages / pathology body weight / physiology cell size pmid:21084397 doi:10.1210/jc.2010-1290 louise mannerås-holm henrik leonhardt malin lönn adipocytes / pathology* adipose tissue / pathology* amyloid / blood body height / physiology glycerol / blood gonadal steroid hormones / blood* lipoprotein lipase / metabolism waist circumference waist-hip ratio

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