Ependymal cells: biology and pathology

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ID: 114469
2009
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Abstract
The literature was reviewed to summarize the current understanding of the role of ciliated ependymal cells in the mammalian brain. Previous reviews were summarized. Publications from the past 10 years highlight interactions between ependymal cells and the subventricular zone and the possible role of restricted ependymal populations in neurogenesis. Ependymal cells provide trophic support and possibly metabolic support for progenitor cells. Channel proteins such as aquaporins may be important for determining water fluxes at the ventricle wall. The junctional and anchoring proteins are now fairly well understood, as are proteins related to cilia function. Defects in ependymal adhesion and cilia function can cause hydrocephalus through several different mechanisms, one possibility being loss of patency of the cerebral aqueduct. Ependymal cells are susceptible to infection by a wide range of common viruses; while they may act as a line of first defense, they eventually succumb to repeated attacks in long-lived organisms. Ciliated ependymal cells are almost certainly important during brain development. However, the widespread absence of ependymal cells from the adult human lateral ventricles suggests that they may have only regionally restricted value in the mature brain of large size.
Reference Key
bigio2009actaependymal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marc R. Del Bigio;Marc R. Del Bigio;
Journal acta neuropathologica
Year 2009
DOI
doi:10.1007/s00401-009-0624-y
URL
https://link.springer.com/article/10.1007/s00401-009-0624-y
Keywords
pathology neurosciences

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