GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition

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ID: 114058
2018
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Abstract
Approximately 10-15% of all bone fractures do not heal properly, causing patient morbidity and additional medical care expenses. Therefore, better mechanism-based fracture repair approaches are needed. In this study, a reduced number of osteoclasts (OCs) and autophagosomes/autolysosomes in OC can be …
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Authors Zhao SJ;Kong FQ;Cai W;Xu T;Zhou ZM;Wang ZB;Xu AD;Yang YQ;Chen J;Tang PY;Wang Q;Cheng L;Luo YJ;Zhou Z;Li LW;Huang YF;Zhao X;Yin GY;Xue MX;Fan J;;
Journal Cell death & disease
Year 2018
DOI
DOI not found
URL
https://www.pubmed.gov/30546041/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Fractures Knockout pmid:30546041 pmc6294144 doi:10.1038/s41419-018-1256-8 shu-jie zhao fan-qi kong jin fan autophagy / genetics* beclin-1 / genetics* cell cycle proteins / genetics* bone / genetics bone / pathology gtpase-activating proteins / genetics* osteoclasts / metabolism phosphorylation proto-oncogene proteins c-bcl-2 / genetics* starvation / genetics starvation / pathology

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