Effects of iron-containing substances on nervous tissue in vitro
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ID: 113951
1970
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Abstract
The effects of different iron-containing substances (ferric and ferrous chloride, hemolyzed blood, iron-dextran) on explants of embryonic mouse spinal cord-ganglion were studied. The main observations were as follows: 1. Macrophages and neuroglial cells easily ingest iron, but neurons only when exposed to a high concentration of iron-dextran. 2. Continous exposure to iron-dextran at a high concentration produced a rapid nonspecific degeneration of neurons. 3. Iron, once taken up by the cells, appeared to persist intracellularly for long periods of time. 4. Autofluorescent lipopigments developed with time in iron exposed explants, probably the result of altered intracellular oxidation. 5. In cultures exposed to iron-dextran for a limited period of time, and then maintained with the oridinary nutrient medium, a remarkable “drop out” of neurons was seen, possibly a late effect of the exposure to iron. Macrophages and neuroglial cells easily ingest iron, but neurons only when exposed to a high concentration of iron-dextran. Continous exposure to iron-dextran at a high concentration produced a rapid nonspecific degeneration of neurons. Iron, once taken up by the cells, appeared to persist intracellularly for long periods of time. Autofluorescent lipopigments developed with time in iron exposed explants, probably the result of altered intracellular oxidation. In cultures exposed to iron-dextran for a limited period of time, and then maintained with the oridinary nutrient medium, a remarkable “drop out” of neurons was seen, possibly a late effect of the exposure to iron.
| Reference Key |
kristensson1970actaeffects
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| Authors | Krister Kristensson;Murray B. Bornstein;Krister Kristensson;Murray B. Bornstein; |
| Journal | acta neuropathologica |
| Year | 1970 |
| DOI |
doi:10.1007/BF00685283
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