Intercellular Ca2+ waves in rat heart muscle
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1998
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Abstract
Confocal laser scanning microscopy was used to visualize intercellular transmission of Ca2+ waves in intact rat ventricular trabeculae micro-injected with the calcium indicator fluo-3.Ca2+ waves usually failed to be transmitted from cell to cell. At identified individual end-to-end cell contacts, successful transmission interspersed with failure, which sometimes occurred despite an apparent small spritz of Ca2+ between cells. The probability of cell to cell transmission (Ptran) was 0.13.Ca2+ waves arose preferentially near junctions of connected cells, where connexin-43 was found, but randomly in enzymatically disconnected heart cells.β-Adrenergic stimulation significantly increased Ptran (to 0.22) and heptanol, an uncoupler of gap junction channels, significantly decreased it (to 0.045).In regions of high [Ca2+]i due to damage, wave frequency decreased markedly with each cell-cell junction passed.The Ca2+ permeability of cardiac gap junctions may be regulated, and the low ability of cardiac gap junctions to transmit Ca2+ may help control the spread of Ca2+ from damaged regions.
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| Authors | Christine Lamont,Paul W. Luther,C. William Balke,W. Gil Wier;Christine Lamont;Paul W. Luther;C. William Balke;W. Gil Wier; |
| Journal | the journal of physiology |
| Year | 1998 |
| DOI |
10.1111/j.1469-7793.1998.669bd.x
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