Uterus Transplantation with Live Donors: Screening Candidates in One French Center

Clicks: 381
ID: 113726
2020
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Abstract
We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.
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Authors Marie Carbonnel;Aurelie Revaux;Elena Menzhulina;Lea Karpel;Renaud Snanoudj;Morgan Le Guen;Dominique De Ziegler;Jean Marc Ayoubi;Carbonnel, Marie;Revaux, Aurelie;Menzhulina, Elena;Karpel, Lea;Snanoudj, Renaud;Le Guen, Morgan;De Ziegler, Dominique;Ayoubi, Jean Marc;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9062001
URL
https://www.mdpi.com/2077-0383/9/6/2001
Keywords
Screening transplantation uterus uterine transplant

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