Oligodendrocytes: biology and pathology

Clicks: 168
ID: 113594
2009
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Abstract
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons. Due to this complex differentiation program, and due to their unique metabolism/physiology, oligodendrocytes count among the most vulnerable cells of the CNS. In this review, we first describe the different steps eventually culminating in the formation of mature oligodendrocytes and myelin sheaths, as they were revealed by studies in rodents. We will then show differences and similarities of human oligodendrocyte development. Finally, we will lay out the different pathways leading to oligodendrocyte and myelin loss in human CNS diseases, and we will reveal the different principles leading to the restoration of myelin sheaths or to a failure to do so.
Reference Key
bradl2009actaoligodendrocytes: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Monika Bradl;Hans Lassmann;Monika Bradl;Hans Lassmann;
Journal acta neuropathologica
Year 2009
DOI
doi:10.1007/s00401-009-0601-5
URL
https://link.springer.com/article/10.1007/s00401-009-0601-5
Keywords
pathology neurosciences

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