Heparan sulfate-like immunoreactivity in the spinal cord in motor neuron disease

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ID: 113589
1970
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Abstract
The spinal cords from eight autopsy cases of sporadic motor neuron disease (MND) and two control cases were immunohistochemically examined using anti-bodies directed to neurofilament proteins (anti-Nf) and to heparan sulfate (HepSS-1). Variable numbers of spheroids were observed in the anterior horns in the MND cases. In one case of MND, one third to half of the remaining anterior horn cells contained conglomerate inclusions in their perikarya. These pathological structures were not encountered in the control cases. The immunohistochemical study revealed that both anti-Nf and HepSS-1 intensely labelled all spheroids and conglomerate inclusions in the MND cases. The colocalization of heparan sulfate with neurofilamentous accumulation suggests that heparan sulfate is required for the aggregation of neurofilaments, resulting in the formation of spheroids and conglomerate inclusions in MND.
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kato1970actaheparan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Takeo Kato;Tadashi Katagiri;Yukihiro Shikama;Keiji Kurita;Itaru Toyoshima;Asao Hirano;Manabu Wada;Hideo Sasaki;Takeo Kato;Tadashi Katagiri;Yukihiro Shikama;Keiji Kurita;Itaru Toyoshima;Asao Hirano;Manabu Wada;Hideo Sasaki;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00334678
URL
https://link.springer.com/article/10.1007/BF00334678
Keywords
pathology neurosciences

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