Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero

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ID: 113548
2017
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Abstract
Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recently reported a fivefold increase in CASPR2-antibodies in mid-gestation sera from mothers of children with intellectual and motor disabilities. Here, we exposed mice in utero to purified IgG from patients with CASPR2-antibodies (CASPR2-IgGs) or from healthy controls (HC-IgGs). CASPR2-IgG but not HC-IgG bound to fetal brain parenchyma, from which CASPR2-antibodies could be eluted. CASPR2-IgG exposed neonates achieved milestones similarly to HC-IgG exposed controls but, when adult, the CASPR2-IgG exposed progeny showed marked social interaction deficits, abnormally located glutamatergic neurons in layers V–VI of the somatosensory cortex, a 16% increase in activated microglia, and a 15–52% decrease in glutamatergic synapses in layers of the prefrontal and somatosensory cortices. Thus, in utero exposure to CASPR2-antibodies led to permanent behavioral, cellular, and synaptic abnormalities. These findings support a pathogenic role for maternal antibodies in human neurodevelopmental conditions, and CASPR2 as a potential target.
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coutinho2017actapersistent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ester Coutinho;David A. Menassa;Leslie Jacobson;Steven J. West;Joana Domingos;Teresa C. Moloney;Bethan Lang;Paul J. Harrison;David L. H. Bennett;David Bannerman;Angela Vincent;Ester Coutinho;David A. Menassa;Leslie Jacobson;Steven J. West;Joana Domingos;Teresa C. Moloney;Bethan Lang;Paul J. Harrison;David L. H. Bennett;David Bannerman;Angela Vincent;
Journal acta neuropathologica
Year 2017
DOI
doi:10.1007/s00401-017-1751-5
URL
https://link.springer.com/article/10.1007/s00401-017-1751-5
Keywords
pathology neurosciences

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