Nodding syndrome in Uganda is a tauopathy

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ID: 113395
2018
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Abstract
Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13–18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic examination revealed tau-immunoreactive neuronal neurofibrillary tangles, pre-tangles, neuropil threads, and dot-like lesions involving the cerebral cortex, subcortical nuclei and brainstem. There was preferential involvement of the frontal and temporal lobes in a patchy distribution, mostly involving the crests of gyri and the superficial cortical lamina. The mesencephalopontine tegmental nuclei, substantia nigra, and locus coeruleus revealed globose neurofibrillary tangles and threads. We conclude that nodding syndrome is a tauopathy and may represent a newly recognized neurodegenerative disease.
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pollanen2018actanodding Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael S. Pollanen;Sylvester Onzivua;Janice Robertson;Paul M. McKeever;Francis Olawa;David L. Kitara;Amanda Fong;Michael S. Pollanen;Sylvester Onzivua;Janice Robertson;Paul M. McKeever;Francis Olawa;David L. Kitara;Amanda Fong;
Journal acta neuropathologica
Year 2018
DOI
doi:10.1007/s00401-018-1909-9
URL
https://link.springer.com/article/10.1007/s00401-018-1909-9
Keywords
pathology neurosciences

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