No chromosomal imbalances detected by comparative genomic hybridisation in subependymal giant cell astrocytomas

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ID: 113342
2002
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Abstract
Eight subependymal giant cell astrocytomas (SEGA) were studied by comparative genomic hybridisation. These consisted of six primary SEGA and two recurrences gained from six paediatric patients suffering from tuberous sclerosis complex (TSC). No DNA copy number changes were found in any of the tumours. Our data show that chromosomal imbalances are absent or very rare events in primary and recurrent SEGA and that no aberrations were detected at the sites of the TSC-associated genes, thus indicating that mutational inactivation of one of the TSC genes is not followed by genomic instability.
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rickert2002actano Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Christian H. Rickert;Werner Paulus;Christian H. Rickert;Werner Paulus;
Journal acta neuropathologica
Year 2002
DOI
doi:10.1007/s00401-002-0544-6
URL
https://link.springer.com/article/10.1007/s00401-002-0544-6
Keywords
pathology neurosciences

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