Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection

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ID: 113170
1997
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Abstract
T lymphocytes play a pivotal role in the immune response during viral infections. In a murine model of experimental respiratory syncytial virus (RSV) infection, mice sensitized to either of the two major glycoproteins of RSV develop distinct patterns of cytokine secretion and lung inflammation upon …
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Authors Srikiatkhachorn A;Braciale TJ;;
Journal The Journal of experimental medicine
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9236194
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't female amino acid sequence P.H.S. Inbred BALB C Molecular Sequence Data Viral Proteins / genetics Knockout respiratory syncytial viruses / immunology* spleen / metabolism hn protein* viral envelope proteins respiratory syncytial virus infections / immunology* respiratory syncytial virus infections / pathology cytotoxicity immunologic spleen / immunology pmid:9236194 pmc2198992 doi:10.1084/jem.186.3.421 a srikiatkhachorn t j braciale cd8-positive t-lymphocytes / immunology cd8-positive t-lymphocytes / virology* cytokines / biosynthesis cytokines / metabolism* down-regulation / immunology* molecular weight pulmonary eosinophilia / immunology* pulmonary eosinophilia / pathology pulmonary eosinophilia / virology recombinant fusion proteins / administration & dosage recombinant fusion proteins / immunology respiratory syncytial virus infections / genetics spleen / virology th2 cells / metabolism* th2 cells / virology viral matrix proteins / administration & dosage viral matrix proteins / genetics viral proteins / administration & dosage

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