Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease

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ID: 112919
2008
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Abstract
This report concerns an immunohistochemical investigation on RNA-related proteins in the basophilic inclusions (BIs) from patients with adult-onset atypical motor neuron disease. Formalin-fixed, paraffin-embedded sections of the motor cortex and the lumbar spinal cord were examined. The BIs appeared blue in color with H&E and Nissl stain, and pink with methylgreen–pyronin stain. Ribonuclease pretreatment abolished the methylgreen–pyronin staining, suggesting that the BIs contained RNA. Immunohistochemically, the BIs were distinctly labeled with the antibodies against poly(A)-binding protein 1, T cell intracellular antigen 1, and ribosomal protein S6. These proteins are essential constituents of stress granules. In contrast, the BIs were not immunoreactive for ribosomal protein L28 and decapping enzyme 1, which are core components of transport ribonucleoprotein particles and processing bodies, respectively. Moreover, the BIs were not immunopositive for TDP-43. Our results imply that translation attenuation could be involved in the processes of BI formation in this disorder.
Reference Key
fujita2008actaimmunohistochemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kengo Fujita;Hidefumi Ito;Satoshi Nakano;Yoshimi Kinoshita;Reika Wate;Hirofumi Kusaka;Kengo Fujita;Hidefumi Ito;Satoshi Nakano;Yoshimi Kinoshita;Reika Wate;Hirofumi Kusaka;
Journal acta neuropathologica
Year 2008
DOI
doi:10.1007/s00401-008-0415-x
URL
https://link.springer.com/article/10.1007/s00401-008-0415-x
Keywords
pathology neurosciences

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