Immunohistochemical observations on rat radial glia: relationship with the origin of ethylnitrosourea-induced tumors

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ID: 112845
1970
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Abstract
Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial antigens has been investigated in this age period in ENU-treated and control rats. Immunohistochemical and immunoelectron microscopical methods have been employed. Vimentin was widely expressed starting from embryonal day 14 (E 14) in the processes of radial glia; as long as radial glia was present, vimentin decorated it. GFAP was, at earliest, observed at E 20 and expressed by glial cells with a stellate, i.e., mature shape. No GFAP-positive radial process was observed. No difference was found between ENU-treated and control rats. Since ENU is most effective in producing tumors when administered at the 16–17th day of fetal life, vimentin-positive radial glia is a candidate target of ENU. The similarity of intermediate filament pattern between radial glia in the late fetal life and tumors induced by transplacental ENU suggests that radial glia might be the cell of origin.
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giordana1970actaimmunohistochemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. T. Giordana;A. Migheli;C. Mocellini;F. Villare;D. Schiffer;M. T. Giordana;A. Migheli;C. Mocellini;F. Villare;D. Schiffer;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00227665
URL
https://link.springer.com/article/10.1007/BF00227665
Keywords
pathology neurosciences

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