Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas

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ID: 112667
1970
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Abstract
Primary glioblastomas develop rapidly de novo through a genetic pathway characterized by amplification/overexpression of EGFR and of MDM2 genes. Secondary glioblastomas develop more slowly through progression from low grade or anaplastic astrocytoma and show a high incidence of a p53 mutation. In the present study, primary and secondary glioblastomas were analyzed for p16 deletions and CDK4 amplification by differential PCR and for loss of expression of the retinoblastoma (RB) gene by immunohistochemistry. Except for one case, alterations in the structure or expression of p16, CDK4 and RB were mutually exclusive. The overall incidence of aberrant expression of these genes coding for components of the cell-cycling-regulatory system was similar in primary (14/28; 50%) and secondary glioblastomas (9/23; 39%). However, p16 deletions were significantly more frequent in the former (10/28; 36%) than in the latter (1/23, 4%; P = 0.0075), suggesting that this alteration constitutes an additional genetic hallmark of the primary (de novo) glioblastoma.
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biernat1970actaalterations Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wojciech Biernat;Yasuo Tohma;Yasuhiro Yonekawa;Paul Kleihues;H. Ohgaki;Wojciech Biernat;Yasuo Tohma;Yasuhiro Yonekawa;Paul Kleihues;H. Ohgaki;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/s004010050711
URL
https://link.springer.com/article/10.1007/s004010050711
Keywords
pathology neurosciences

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