In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion

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ID: 112634
1994
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Abstract
A series of sulfonic acid polymers were shown to be potent and selective inhibitors of respiratory syncytial virus (RSV) and influenza A virus. The compounds inhibit the replication of RSV and influenza A virus in HeLa and MDCK cells, at concentrations of 0.16 and 4.0 micrograms/ml, respectively, an …
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Authors Ikeda S;Neyts J;Verma S;Wickramasinghe A;Mohan P;De Clercq E;;
Journal Antimicrobial agents and chemotherapy
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8192454
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Comparative Study Inbred BALB C Receptors microbial sensitivity tests respiratory syncytial virus infections / drug therapy* pmid:8192454 pmc284437 doi:10.1128/aac.38.2.256 s ikeda j neyts e de clercq antiviral agents / pharmacology* hela cells influenza a virus / drug effects* influenza a virus / physiology influenza b virus / drug effects* influenza b virus / physiology influenza human / drug therapy* human / prevention & control scid polymers / pharmacology virus / metabolism* respiratory syncytial virus infections / prevention & control respiratory syncytial virus human / drug effects* sulfonic acids / pharmacology*

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