Organoids in Translational Oncology

Clicks: 320
ID: 112391
2020
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Abstract
Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out on tissue culture plates (TCPs) and other 2D samples. In this context, 3D printing has greatly improved the biofabrication of new biological matrices that mimic the extracellular environments, which may characterize healthy from cancerous tissues. Organoids have recently been described in several reports on scientific literature. The term that better describes such organoids-based tumoral tissues is “tumoroids”. Tumoroids are substantially “tumor-like organoids”, typically deriving from primary tumors harvested from patients. This topical review aims to give an update on organoids applied in translational medicine, paying specific attention to their use in the investigation of the main molecular mechanisms of cancer onset and growth, and on the most impacting strategies for effective targeted therapies.
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tatullo2020journalorganoids Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marco Tatullo;Benedetta Marrelli;Caterina Benincasa;Elisabetta Aiello;Irina Makeeva;Barbara Zavan;Andrea Ballini;Danila De Vito;Gianrico Spagnuolo;Tatullo, Marco;Marrelli, Benedetta;Benincasa, Caterina;Aiello, Elisabetta;Makeeva, Irina;Zavan, Barbara;Ballini, Andrea;De Vito, Danila;Spagnuolo, Gianrico;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9092774
URL
https://www.mdpi.com/2077-0383/9/9/2774/htm
Keywords
scaffolds tissue engineering translational medicine

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