Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

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ID: 112370
2017
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Abstract
The cause of polycystic ovary syndrome (PCOS) is unknown, but androgen excess is a key feature. We combined a hyperandrogenized PCOS mouse model with global and tissue- and cell-specific androgen-resistant mouse lines to uncover the sites of androgen action that initiate PCOS. We demonstrate that direct androgen actions, particularly in neurons but less so in granulosa cells, are required for the development of key reproductive and metabolic PCOS features. These data highlight the previously overlooked importance of extraovarian neuroendocrine androgen action in the origins of PCOS. Targeting androgen-driven mechanisms may represent new options for developing a mechanism-based treatment of PCOS.
Reference Key
caldwell2017proceedingsneuroendocrine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Aimee S. L. Caldwell;Melissa C. Edwards;Reena Desai;Mark Jimenez;Robert B. Gilchrist;David J. Handelsman;Kirsty A. Walters;Aimee S. L. Caldwell;Melissa C. Edwards;Reena Desai;Mark Jimenez;Robert B. Gilchrist;David J. Handelsman;Kirsty A. Walters;
Journal proceedings of the national academy of sciences
Year 2017
DOI
10.1073/pnas.1616467114
URL
http://dx.doi.org/10.1073/pnas.1616467114
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Disease Models animal* Cells Cultured Receptors Knockout polycystic ovary syndrome / metabolism polycystic ovary syndrome / pathology* neurons / drug effects neurons / metabolism androgens / pharmacology* melissa c edwards kirsty a walters pmid:28320971 pmc5402450 doi:10.1073/pnas.1616467114 aimee s l caldwell estrous cycle / drug effects granulosa cells / drug effects granulosa cells / metabolism granulosa cells / pathology* neurons / pathology* neurosecretory systems / drug effects* polycystic ovary syndrome / drug therapy androgen / physiology*

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