Primary cerebellar extramedullary myeloid cell tumor mimicking oligodendroglioma

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ID: 112258
1970
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Abstract
Extramedullary myeloid cell tumors (EMCTs) are tumors consisting of immature cells of the myeloid series that occur outside the bone marrow. Most of them are associated with acute myelogenous leukemia or other myeloproliferative disorders, and a small number occur as primary lesions, i.e., are not associated with hematological disorders. Occurrence inside the cranium is rare, and there has been only one case of primary EMCT involving the cerebellum reported in the literature. The case we report here is a blastic EMCT occurring in the cerebellum of a 3-year-old boy who had no signs of leukemia or any hematological disorder throughout the entire course. The cerebellar tumor was at first misdiagnosed as an “oligodendroglioma” because of the uniformity and “fried egg” artifact of the tumor cells. The tumor disappeared during chemotherapy consisting of 12 treatments. However, it recurred and metastasized to the cerebrospinal fluid (CSF) shortly after the therapy was completed. A diagnosis of EMCT was suspected because of the presence of immature myeloid cells in the CSF, and was confirmed by anti-myeloperoxidase and anti-lysozyme immunoreactivity of the cerebellar tumor. The patient succumbed 1 year and 3 months after the first presentation of the disease.
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Authors D. M.-T. Ho;Tai-Tong Wong;Wan-Yuo Guo;Kai-Ping Chang;Sang-Hue Yen;D. M.-T. Ho;Tai-Tong Wong;Wan-Yuo Guo;Kai-Ping Chang;Sang-Hue Yen;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/s004010050725
URL
https://link.springer.com/article/10.1007/s004010050725
Keywords
pathology neurosciences

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