Diffuse type of senile plaques in the brains of Alzheimer-type dementia

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ID: 112040
1970
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Abstract
We studied the nature of diffuse type of senile plaques (SP) in the brains of six autopsied subjects with Alzheimer-type dementia (ATD). The densities of SP in the entorhinal cortex were evaluated using serial sections stained by four different methods. Compared with β protein immunostaining (100% as a reference), the modified Bielschowsky stain (103%) and the periodic acid-methenamine silver (PAM) stain (109%) labeled similar numbers of SP, whereas the Bodian stain labeled only a minor proportion (42%) of these. The vast majority of Bodian-negative plaques were diffuse plaques, which were seen as ill-defined areas of fine fibrillar material after β protein immunostain with formic acid pretreatment, modified Bielschowsky stain, and PAM stain. They were not stained by Congo red or periodic acid-Schiff stains. Double staining using Bodian and β protein methods demonstrated that diffuse plaques were free of swollen neurites. Argyrophilia of the diffuse plaques shown by the modified Bielschowsky and PAM stains, became undetectable when sections were pretreated with formic acid. Such treatment made the diffuse plaques immunoreactive to β protein antiserum, suggesting that diffuse plaques consisted mainly of amyloid, but not neuritic components. The diffuse plaques were distributed in various cortical areas and in the amygdala, and comprised a considerable population of the SP in the ATD brains.
Reference Key
yamaguchi1970actadiffuse Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors H. Yamaguchi;S. Hirai;M. Morimatsu;M. Shoji;Y. Harigaya;H. Yamaguchi;S. Hirai;M. Morimatsu;M. Shoji;Y. Harigaya;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687420
URL
https://link.springer.com/article/10.1007/BF00687420
Keywords
pathology neurosciences

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