Lhermitte-Duclos disease

Clicks: 103
ID: 111978
1970
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Abstract
Immunocytochemical studies were carried out on two previously reported autopsy cases of Lhermitte-Duclos disease. The unaffected cerebellar cortex adjacent to the lesions served as control. The findings supported the view, previously expressed by one of the authors, of a heterogeneous neuronal structure of the lesion, consisting of at least two cell types. No further light was thrown on the predominant medium-sized cells, believed to represent hypertrophic internal granular neurons. On the other hand the large cells shared a number of features with Purkinje cells. In particular they were recognized by the pan-T-cell antibody anti-Leu-4, were surrounded by axosomatic synapses visualized by the antisynaptic vesicle glycoprotein antibody SV2, and contained both nonphosphorylated and phosphorylated neurofilament epitopes. It is suggested that these cells represent dysplastic Purkinje cells. The lesion therefore appears to be a complex hamartoma rather than a simple hypertrophy of the internal granular neurons.
Reference Key
shiurba1970actalhermitte-duclos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R. A. Shiurba;E. C. Gessaga;L. F. Eng;L. A. Sternberger;N. H. Sternberger;H. Urich;R. A. Shiurba;E. C. Gessaga;L. F. Eng;L. A. Sternberger;N. H. Sternberger;H. Urich;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687134
URL
https://link.springer.com/article/10.1007/BF00687134
Keywords
pathology neurosciences

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