Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage

Administration National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine behavior research support non-u.s. gov't male Animal Knockout microscopy electron pmid:19577336 doi:10.1016/j.neurobiolaging.2009.05.017 sun-uk kim mei-hua jin dong-seok lee oral aging / physiology* antioxidants / administration & dosage creb-binding protein / genetics creb-binding protein / metabolism cognition / drug effects cognition / physiology* cyclic amp-dependent protein kinases / metabolism enzyme activation / drug effects enzyme activation / genetics extracellular signal-regulated map kinases / metabolism hippocampus / cytology* learning disabilities / diet therapy learning disabilities / genetics long-term potentiation / drug effects long-term potentiation / genetics malondialdehyde / metabolism maze learning / physiology transmission / methods mitochondria / pathology neurons / drug effects neurons / metabolism neurons / physiology* neurons / ultrastructure peroxiredoxins / deficiency peroxiredoxins / metabolism* protein carbonylation / drug effects reactive oxygen species vitamin e / administration & dosage