Intestinal mucosal inflammation associated with human immunodeficiency virus infection

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ID: 111645
1970
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Abstract
The role of the human immunodeficiency virus type-1 (HIV) in producing intestinal disease was studied prospectively in 74 HIV-infected individuals with (43) or without (31) the acquired immunodeficiency syndrome (AIDS). Thirty-one subjects had enteric infections; all but one had AIDS. Alteration in bowell habits was the most common symptom and occurred independently of enteric infections. Abnormal histopathology was present in 69% of cases, and the finding was associated with altered bowel habits. An HIV-associated protein, p24, was detected in 71% of biopsies by ELISA assay. Tissue p24 contents varied with disease stage and were highest in HIV-infected individuals without AIDS (Walter Reed classes 3 and 4). Tissue p24 detection was associated with both altered bowel habits and histologic mucosal abnormalities. Tissue contents of the cytokines, tumor necrosis factor-α and interleukin-1β, were higher in HIV-infected individuals than in controls and their elevations were independent of enteric infection. We conclude that HIV reactivation in the intestinal mucosa may be associated with an inflammatory bowel syndrome in the absence of other enteric pathogens.
Reference Key
kotler1970digestiveintestinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Donald P. Kotler;Safak Reka;Frederic Clayton;Donald P. Kotler;Safak Reka;Frederic Clayton;
Journal Digestive diseases and sciences
Year 1970
DOI
doi:10.1007/BF01295730
URL
http://dx.doi.org/10.1007/BF01295730
Keywords
oncology biochemistry hepatology gastroenterology general transplant surgery biopsy National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't female male Comparative Study Prospective Studies P.H.S. chi-square distribution hiv infections / complications* hiv infections / epidemiology hiv-1* analysis of variance acquired immunodeficiency syndrome / complications s reka d p kotler f clayton acquired immunodeficiency syndrome / pathology acquired immunodeficiency syndrome / epidemiology acquired immunodeficiency syndrome / microbiology hiv infections / pathology hiv infections / microbiology hiv core protein p24 / analysis pmid:8508707 doi:10.1007/bf01295730 colon / chemistry colon / microbiology colon / pathology cytokines / analysis inflammatory bowel diseases / epidemiology inflammatory bowel diseases / etiology* inflammatory bowel diseases / microbiology inflammatory bowel diseases / pathology intestinal mucosa / chemistry intestinal mucosa / microbiology intestinal mucosa / pathology*

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