Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome

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ID: 111508
2005
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Abstract
Enhanced basal and ACTH-stimulated adrenal androgen levels in PA female monkeys may reflect up-regulation of 17,20 lyase activity in the adrenal zona reticularis, causing adrenal androgen excess comparable with that found in PCOS women with adrenal androgen excess. These findings open the possibilit …
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Authors Zhou R;Bird IM;Dumesic DA;Abbott DH;;
Journal the journal of clinical endocrinology and metabolism
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16174719
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine pregnancy research support female N.I.H. Extramural david h abbott Polycystic Ovary Syndrome / metabolism* macaca mulatta pmid:16174719 pmc1350929 doi:10.1210/jc.2005-0691 rao zhou ian m bird adrenal glands / metabolism* adrenocorticotropic hormone / pharmacology androgens / metabolism* area under curve dehydroepiandrosterone / blood dexamethasone / pharmacology fetus / metabolism* hormones / blood hyperandrogenism / etiology* hyperandrogenism / metabolism* prenatal exposure delayed effects* steroids / blood

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