C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue

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2000
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Abstract
Knockout of C/EBPalpha causes a severe loss of liver function and, subsequently, neonatal lethality in mice. By using a gene replacement approach, we generated a new C/EBPalpha-null mouse strain in which C/EBPbeta, in addition to its own expression, substituted for C/EBPalpha expression in tissues. …
Reference Key
ss2000molecularc/ebpbeta, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chen SS;Chen JF;Johnson PF;Muppala V;Lee YH;;
Journal molecular and cellular biology
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10982846##publication-types
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL RNA animals pubmed abstract nih national institutes of health national library of medicine female male Comparative Study genetic* CCAAT-Enhancer-Binding Proteins Genotype pmid:10982846 PMC86283 doi:10.1128/mcb.20.19.7292-7299.2000 S S Chen J F Chen Y H Lee Adipose Tissue / metabolism* Blood Glucose / metabolism Chimera Complement Factor D Crosses Cysteine Dioxygenase DNA-Binding Proteins / biosynthesis DNA-Binding Proteins / deficiency DNA-Binding Proteins / genetics* DNA-Binding Proteins / physiology* Dioxygenases* Fertility Gene Expression Regulation* Leptin / biosynthesis Leptin / genetics Lipid Metabolism Liver / metabolism* Liver Failure / genetics* Liver Failure / metabolism Liver Failure / prevention & control Knockout Nuclear Proteins / biosynthesis Nuclear Proteins / deficiency Nuclear Proteins / genetics* Nuclear Proteins / physiology* Organ Specificity Oxygenases / biosynthesis Oxygenases / genetics Promoter Regions Messenger / biosynthesis Messenger / genetics Recombinant Fusion Proteins / biosynthesis Recombinant Fusion Proteins / physiology Serine Endopeptidases / biosynthesis Serine Endopeptidases / genetics Transferrin / biosynthesis Transferrin / genetics

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