Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

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ID: 111380
1970
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Abstract
Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically disease brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.
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akiyama1970actaexpression Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Haruhiko Akiyama;Toshio Kawamata;Tatsuo Yamada;Ikuo Tooyama;Tsyoshi Ishii;Patrick L. McGeer;Haruhiko Akiyama;Toshio Kawamata;Tatsuo Yamada;Ikuo Tooyama;Tsyoshi Ishii;Patrick L. McGeer;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00334673
URL
https://link.springer.com/article/10.1007/BF00334673
Keywords
pathology neurosciences

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