Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study
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2020
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Abstract
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We evaluated the cross-sectional association of serum proteomic and metabolomic markers with three dietary patterns: the Alternative Healthy Eating Index (AHEI), the Dietary Approaches to Stop Hypertension (DASH) diet; and a Mediterranean-style (MDS) diet. We examined participants from the Framingham Offspring Study (mean age; 55 years; 52% women) who had complete proteomic (n = 1713) and metabolomic (n = 2284) data; using food frequency questionnaires to derive dietary pattern indices. Proteins and metabolites were quantified using the SomaScan platform and liquid chromatography/tandem mass spectrometry; respectively. We used multivariable-adjusted linear regression models to relate each dietary pattern index (independent variables) to each proteomic and metabolomic marker (dependent variables). Of the 1373 proteins; 103 were associated with at least one dietary pattern (48 with AHEI; 83 with DASH; and 8 with MDS; all false discovery rate [FDR] ≤ 0.05). We identified unique associations between dietary patterns and proteins (17 with AHEI; 52 with DASH; and 3 with MDS; all FDR ≤ 0.05). Significant proteins enriched biological pathways involved in cellular metabolism/proliferation and immune response/inflammation. Of the 216 metabolites; 65 were associated with at least one dietary pattern (38 with AHEI; 43 with DASH; and 50 with MDS; all FDR ≤ 0.05). All three dietary patterns were associated with a common signature of 24 metabolites (63% lipids). Proteins and metabolites associated with dietary patterns may help characterize intermediate phenotypes that provide insights into the molecular mechanisms mediating diet-related disease. Our findings warrant replication in independent populations
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vasan2020nutrientsproteomic
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| Authors | Maura E. Walker,Rebecca J. Song,Xiang Xu,Robert E. Gerszten,Debby Ngo,Clary B. Clish,Laura Corlin,Jiantao Ma,Vanessa Xanthakis,Paul F Jacques,Ramachandran S. Vasan;Maura E. Walker;Rebecca J. Song;Xiang Xu;Robert E. Gerszten;Debby Ngo;Clary B. Clish;Laura Corlin;Jiantao Ma;Vanessa Xanthakis;Paul F Jacques;Ramachandran S. Vasan; |
| Journal | Nutrients |
| Year | 2020 |
| DOI |
10.3390/nu12051476
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