The Role of Dendritic Cells in TB and HIV Infection

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ID: 111048
2020
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Abstract
Dendritic cells are the principal antigen-presenting cells (APCs) in the host defense mechanism. An altered dendritic cell response increases the risk of susceptibility of infections, such as Mycobacterium tuberculosis (M. tb), and the survival of the human immunodeficiency virus (HIV). The altered response of dendritic cells leads to decreased activity of T-helper-1 (Th1), Th2, Regulatory T cells (Tregs), and Th17 cells in tuberculosis (TB) infections due to a diminishment of cytokine release from these APCs, while HIV infection leads to DC maturation, allowing DCs to migrate to lymph nodes and the sub-mucosa where they then transfer HIV to CD4 T cells, although there is controversy around this topic. Increases in the levels of the antioxidant glutathione (GSH) plays a critical role in maintaining dendritic cell redox homeostasis, leading to an adequate immune response with sufficient cytokine release and a subsequent robust immune response. Thus, an understanding of the intricate pathways involved in the dendritic cell response are needed to prevent co-infections and co-morbidities in individuals with TB and HIV.
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Authors Rachel Abrahem;Emerald Chiang;Joseph Haquang;Amy Nham;Yu-Sam Ting;Vishwanath Venketaraman;Abrahem, Rachel;Chiang, Emerald;Haquang, Joseph;Nham, Amy;Ting, Yu-Sam;Venketaraman, Vishwanath;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9082661
URL
https://www.mdpi.com/2077-0383/9/8/2661/htm
Keywords
Mycobacterium tuberculosis hiv immune responses dendritic cells tb National Center for Biotechnology Information NCBI NLM MEDLINE review pubmed abstract nih national institutes of health national library of medicine pmid:32824563 pmc7465216 doi:10.3390/jcm9082661 rachel abrahem emerald chiang vishwanath venketaraman

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