Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

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ID: 110846
2003
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Abstract
The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for infections. The relationship between antimicrobial drug concentration and infecting pathogen population reduction is of primary interest. Using da …
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Authors Jumbe N;Louie A;Leary R;Liu W;Deziel MR;Tam VH;Bachhawat R;Freeman C;Kahn JB;Bush K;Dudley MN;Miller MH;Drusano GL;;
Journal The Journal of clinical investigation
Year 2003
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/12865415
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't female mutation drug resistance multiple time factors inbred icr microbial* pseudomonas infections / drug therapy* pmid:12865415 pmc164285 doi:10.1172/jci16814 nelson jumbe arnold louie george l drusano anti-bacterial agents / pharmacology* dose-response relationship drug kinetics theoretical monte carlo method ofloxacin / pharmacology pseudomonas aeruginosa / metabolism pseudomonas aeruginosa / pathogenicity quinolones / pharmacology

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